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Without spoilers, I would like to know too. I tried limit my rests at first, but gave up on that when stuff got annoyingly difficult.
I’m soon done with the first area and only thing I know so far is that on your second full rest theres a small main plot progression. Other than that no quests seemingly have had time limit so far, I could leave them right before a hard boss battle with civilians in immediate danger and can come back many rests later and nothing has changed.
Fallout one was annoying on my first playthrough. But once I knew, it was no longer a problem.
I dont mind time limits. I would just want to know about them before-hand. Get some kind of hint early on that time matters in this game. Because by regular game convention it never does. Games are usually balanced against if it is a time limit or not. Deus Ex Human Revolution gave that hint, but then nothing else had time limits after that first quest. Thats annoying too, but less so.